Rate of change in early Huntington's disease: a clinicometric analysis.
Identifieur interne : 000C41 ( Main/Exploration ); précédent : 000C40; suivant : 000C42Rate of change in early Huntington's disease: a clinicometric analysis.
Auteurs : Christina Meyer [Allemagne] ; Bernhard Landwehrmeyer ; Carsten Schwenke ; Adam Doble ; Michael Orth ; Albert C. LudolphSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- complications : Huntington Disease.
- diagnosis : Huntington Disease.
- etiology : Behavioral Symptoms, Cognition Disorders.
- Adult, Aged, Disease Progression, Female, Humans, Linear Models, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.
Abstract
Sensitive outcome measures for patients with Huntington's disease (HD) are required for future clinical trials. Longitudinal data were collected from a 3-year study of 379 patients suffering from early HD who were not treated by antipsychotics. Progression of UHDRS item scores was evaluated by linear regression and slope, whereas correlation coefficient, standard error, and P values were estimated on the basis of the data of eight evaluations from screening to study end (36 months). For the functional assessment dimension, the proportion of "no" responses at baseline and at study end was determined. Linear progression was observed for the motor score and for all three functional measures (i.e., functional assessment score, independence assessment score, and total functional capacity score). In contrast, there was little evidence for progression of the behavioral assessment score over the study period, whereas the cognitive assessment score was intermediate. Twenty-two motor-score items showed linear progression, with a slope of >0.003. These included all chorea items, finger tapping and pronation/supination (left and right), gait, tongue protrusion, and tandem walking. Different symptom domains and individual items evolved at different rates in this group of patients suffering from early HD. It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies.
DOI: 10.1002/mds.23847
PubMed: 22095693
Affiliations:
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Christina.Meyer@Uni-Ulm.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name></author><author><name sortKey="Schwenke, Carsten" sort="Schwenke, Carsten" uniqKey="Schwenke C" first="Carsten" last="Schwenke">Carsten Schwenke</name></author><author><name sortKey="Doble, Adam" sort="Doble, Adam" uniqKey="Doble A" first="Adam" last="Doble">Adam Doble</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.23847</idno><idno type="RBID">pubmed:22095693</idno><idno type="pmid">22095693</idno><idno type="wicri:Area/PubMed/Corpus">000F63</idno><idno type="wicri:Area/PubMed/Curation">000F63</idno><idno type="wicri:Area/PubMed/Checkpoint">000C59</idno><idno type="wicri:Area/Ncbi/Merge">003467</idno><idno type="wicri:Area/Ncbi/Curation">003467</idno><idno type="wicri:Area/Ncbi/Checkpoint">003467</idno><idno type="wicri:Area/Main/Merge">000C51</idno><idno type="wicri:Area/Main/Curation">000C41</idno><idno type="wicri:Area/Main/Exploration">000C41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rate of change in early Huntington's disease: a clinicometric analysis.</title><author><name sortKey="Meyer, Christina" sort="Meyer, Christina" uniqKey="Meyer C" first="Christina" last="Meyer">Christina Meyer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany. Christina.Meyer@Uni-Ulm.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name></author><author><name sortKey="Schwenke, Carsten" sort="Schwenke, Carsten" uniqKey="Schwenke C" first="Carsten" last="Schwenke">Carsten Schwenke</name></author><author><name sortKey="Doble, Adam" sort="Doble, Adam" uniqKey="Doble A" first="Adam" last="Doble">Adam Doble</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Behavioral Symptoms (etiology)</term><term>Cognition Disorders (etiology)</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (diagnosis)</term><term>Linear Models</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Behavioral Symptoms</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sensitive outcome measures for patients with Huntington's disease (HD) are required for future clinical trials. Longitudinal data were collected from a 3-year study of 379 patients suffering from early HD who were not treated by antipsychotics. Progression of UHDRS item scores was evaluated by linear regression and slope, whereas correlation coefficient, standard error, and P values were estimated on the basis of the data of eight evaluations from screening to study end (36 months). For the functional assessment dimension, the proportion of "no" responses at baseline and at study end was determined. Linear progression was observed for the motor score and for all three functional measures (i.e., functional assessment score, independence assessment score, and total functional capacity score). In contrast, there was little evidence for progression of the behavioral assessment score over the study period, whereas the cognitive assessment score was intermediate. Twenty-two motor-score items showed linear progression, with a slope of >0.003. These included all chorea items, finger tapping and pronation/supination (left and right), gait, tongue protrusion, and tandem walking. Different symptom domains and individual items evolved at different rates in this group of patients suffering from early HD. It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><noCountry><name sortKey="Doble, Adam" sort="Doble, Adam" uniqKey="Doble A" first="Adam" last="Doble">Adam Doble</name><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><name sortKey="Schwenke, Carsten" sort="Schwenke, Carsten" uniqKey="Schwenke C" first="Carsten" last="Schwenke">Carsten Schwenke</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Meyer, Christina" sort="Meyer, Christina" uniqKey="Meyer C" first="Christina" last="Meyer">Christina Meyer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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